C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/203 (2006.01) A61K 47/30 (2006.01) A61K 47/32 (2006.01) A61L 27/54 (2006.01) A61L 29/16 (2006.01) A61L 31/16 (2006.01) C07C 39/21 (2006.01) C07C 69/157 (2006.01) C07C 69/96 (2006.01) C08F 220/28 (2006.01) C08F 220/30 (2006.01)
Patent
CA 2568472
The present invention relates to polymeric compositions for controlled release or delivery of pharmacologically active agents. Each polymeric composition comprises a biocompatible polymeric matrix containing at least one pharmacologically active agent that is susceptible to oxidative degradation. The biocompatible polymeric matrix comprises at least a first polymeric material with an active antioxidant functional moiety covalently bound thereto in sufficient amount for protecting the at least one pharmacologically active agent against oxidative degradation. Optionally, the biocompatible polymeric matrix further comprises a second polymeric material that is essentially free of covalently bound active antioxidant functional moiety. The present invention also relates to a medical device that comprises an implantable structure, while at least a portion of the implantable structure either comprises or is coated with at least one of the above- described polymeric compositions.
Cordis Corporation
Sim & Mcburney
LandOfFree
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