Solid dose nanoparticulate compositions

Details Solid dose nanoparticulate compositions Solid dose nanoparticulate compositions

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2416109

Disclosed are solid dose nanoparticulate compositions comprising a poorly soluble active agent, at least one polymeric surface stabilizer, and dioctyl sodium sulfosuccinate (DOSS). The solid dose compositions exhibit superior redispersibility of the nanoparticulate composition upon administration to a mammal, such as a human or animal. The invention also describes methods of making and using such compositions.

L'invention concerne des compositions nanoparticulaires à doses solides comprenant un agent actif peu soluble, au moins un stabilisateur de surface polymérique, et du sulfosuccinate de sodium dioctylique (DOSS). Les compositions à doses solides présentent une redispersibilité supérieure de la composition nanoparticulaire lors de l'administration à un mammifère, par exemple à un homme ou à un animal. L'invention concerne également des procédes de fabrication et d'utilisation de ces compositions.

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