Receptor tyrosine kinase genes

Details Receptor tyrosine kinase genes Receptor tyrosine kinase genes

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C07H 21/00 (2006.01) C07K 14/71 (2006.01) C07K 16/46 (2006.01) C12N 5/12 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2271950

The specification describes isolated, purified, or enriched nucleic acid molecules which correspond to particular genes encoding kinases, and to fragments of such genes, as well as the polypeptides encoded by such nucleic acids and antibodies specific for those polypeptides. Also disclosed are methods using such nucleic acid molecules, polypeptides, or antibodies for isolating the full coding sequences for those kinases, for determining the expression patterns and levels for those genes, for screening for agents which modulate the activity of one of the kinases, and for diagnosing or treating a disease associated with one of the kinases.

L'invention concerne des molécules d'acide nucléique isolées, purifiées ou enrichies correspondant à des gènes particuliers codant des kinases, et à des fragments de tels gènes ainsi que les polypeptides codés par de tels acides nucléiques et des anticorps spécifiques contre ces polypeptides. L'invention concerne également des procédés faisant appel à de telles molécules d'acide nucléique, de tels polypeptides ou de tels anticorps afin d'isoler les séquences codantes entières de ces kinases, de déterminer les modèles et niveaux d'expression de ces gènes, de cribler pour obtenir des agents modulant l'activité de l'une des kinases, et de diagnostiquer ou traiter une maladie associée à l'une des kinases.

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