Influenza virus-like particles (vlps) comprising hemagglutinin

Details Influenza virus-like particles (vlps) comprising hemagglutinin Influenza virus-like particles (vlps) comprising hemagglutinin

C - Chemistry, Metallurgy

12

N

C12N 15/82 (2006.01) A61K 39/145 (2006.01) A61P 31/16 (2006.01) C07K 14/11 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 15/44 (2006.01)

Patent

CA 2730185

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA of type A/California/04/09 in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein of type A/California/04/09 and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA of type A/California/04/09 as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.

L'invention porte sur un procédé pour la synthèse de particules du type virus (VLP) de la grippe à l'intérieur d'une plante ou d'une partie d'une plante. Le procédé comprend l'expression de HA de la grippe du type A/Californie/04/09 dans des plantes et la purification par chromatographie d'exclusion diffusion. L'invention porte également sur une VLP comprenant la protéine HA de la grippe de type A/Californie/04/09 et des lipides végétaux. L'invention porte également sur un acide nucléique codant pour HA de la grippe du type A/Californie/04/09 ainsi que sur des vecteurs. Les VLP peuvent être utilisées pour formuler des vaccins contre la grippe ou peuvent être utilisées pour enrichir des vaccins existants.

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