Use of hydroxychloroquine for treatment of graft-versus-host...

Details Use of hydroxychloroquine for treatment of graft-versus-host... Use of hydroxychloroquine for treatment of graft-versus-host...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 31/47 (2006.01) A61K 31/57 (2006.01) A61K 38/13 (2006.01)

Patent

CA 2134413

Disclosed is a pharmaceutical composition for treating graft-versus-host disease comprising an effective amount of hydroxychloroquine in admixture with a pharmaceutically acceptable carrier or diluent. Also disclosed is a pharmaceutical composition for suppressing alloreactivity arising from reactions of donor T lymphocytes against recipient cells comprising an amount of hydroxychloroquine effective to suppress such alloreactivity, in admixture with a pharmaceutically acceptable carrier or diluent.

Divulgation d'une composition pharmaceutique pour traiter la réaction du greffon contre l'hôte, comprenant une quantité efficace d'hydroxychloroquine mélangée avec un excipient ou un diluant d'utilisation pharmaceutique. Est également dévoilée une composition pharmaceutique qui supprime l'alloréactivité découlant de réactions de lymphocytes T du donneur dirigées contre les cellules du receveur, comprenant une quantité d'hydroxychloroquine efficace pour supprimer une telle alloréactivité, en mélange avec un excipient ou un diluant d'utilisation pharmaceutique.

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