G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/48 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2525743
The present invention provides biomolecules and the use of these biomolecules for the differential diagnosis of colorectal cancer or a non-malignant disease of the large intestine. In particular the present invention provides methods for detecting biomolecules within a test sample as well as a database comprising of mass profiles of biomolecules specific for healthy subjects, subjects having a precancerous lesion of the large intestine, subjects having a colorectal cancer or a metastasised colorectal cancer or subjects having a non-malignant disease of the large intestine. Furthermore, the present invention provides methods for the characterization of said biomolecules using gas phase ion spectrometry. In addition, the present invention provides methods for the identification of said biomolecules provided that they are proteins or polypeptides. The invention further provides kits for the differential diagnosis of colorectal cancer or a non-malignant disease of the large intestine.
L'invention concerne des biomolécules et leur utilisation afin d'effectuer un diagnostic différentiel du cancer colorectal et/ou d'une maladie bénigne du gros intestin. D'une manière plus spécifique, l'invention concerne des méthodes permettant de détecter des biomolécules dans un échantillon d'essai ainsi que dans une base de données comprenant des profils de masse de biomolécules spécifiques de sujets sains, de sujets souffrant d'une lésion précancéreuse du gros intestin, de sujets souffrant d'un cancer colorectal ou d'un cancer colorectal métastasé ou de sujets souffrant d'une maladie bénigne du gros intestin. L'invention concerne également des méthodes permettant de caractériser lesdites biomolécules au moyen de la spectrométrie d'ions en phase gazeuse. L'invention concerne en outre des méthodes permettant d'identifier lesdites biomolécules à la condition qu'elles soient des protéines ou des polypeptides. L'invention concerne enfin des trousses permettant d'effectuer un diagnostic différentiel du cancer colorectal et/ou d'une maladie bénigne du gros intestin.
Meuer Jorn
Wiemer Jan
Europroteome Ag
Meuer Jorn
Ridout & Maybee Llp
Wiemer Jan
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