Therapeutic combinations for musculoskeletal frailty

Details Therapeutic combinations for musculoskeletal frailty Therapeutic combinations for musculoskeletal frailty

A - Human Necessities

61

K

A61K 31/44 (2006.01)

Patent

CA 2335112

This invention is directed to pharmaceutical combination compositions and methods comprising (-)-cis-6- phenyl-5-(4- (2-pyrrolidin-1- yl-ethoxy) - phenyl)- 5,6,7,8- tetrahydronaphthalene -2-ol or a pharmaceutically acceptable salt thereof and 2-amino-N-(1(R) -(2,4-difluoro- benzyloxymethyl) -2-oxo-2-(3- oxo-3a(R) -pyridin-2- ylmethyl)-2-( 2,2,2-trifluoro-ethyl) -2,3,3a,4,6,7 - hexahydro -pyrazolo [4,3-c]pyridin -5-yl)-ethyl) -2-methyl-propionamide or a pharmaceutically acceptable salt thereof, methods of using such compositions and kits containing such compositions. The compositions are useful for treating musculoskeletal frailty, including osteoporosis, osteoporotic fracture, low bone mass, frailty and low muscle mass.

Cette invention concerne des compositions et des méthodes de combinaisons pharmaceutiques comprenant (-)-cis-6-phényl-5-(4-(2-pyrrolidin-1-yl-éthoxy)-phényl)-5,6,7,8-tétrahydronaphtalène-2-ol ou un sel acceptable sur le plan pharmaceutique de celui-ci et 2-amino-N-(1(R)-(2,4-difluoro-benzyloxyméthyl)-2-oxo-2-(3-oxo-3a(R)-pyridin-2-ylméthyl)-2-(2,2,2-trifluoro-éthyl)-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridin-5-yl)-éthyl)-2-méthyl-propionamide ou un sel acceptable sur le plan pharmaceutique, et des procédés d'utilisation de ces compositions ainsi que des kits contenant lesdites compositions. Les compositions sont utiles pour traiter la fragilité musculo-squelettique, notamment l'ostéoporose, les fractures ostéoporotiques, la faible masse osseuse, la fragilité et la faible masse musculaire.

Affiliated with

Also associated with

Rating

Therapeutic combinations for musculoskeletal frailty does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic combinations for musculoskeletal frailty, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic combinations for musculoskeletal frailty will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1885759