Method of treating cancer

Details Method of treating cancer Method of treating cancer

A - Human Necessities

61

K

A61K 31/517 (2006.01) A61K 31/395 (2006.01) A61K 45/06 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2749424

The present invention relates to a method of treating or preventing hyperproliferative disease in a body tissue of a subject, comprising the steps of administering to a subject in need thereof a therapeutically effective amount of an agent that in-duces double strand breaks in the DNA of the hyperproliferative cells of said body tissue; and subjecting the hyperproliferative cells of said body tissue prior to, simultaneously with or subsequent to step a) to hyperthermia to thereby induce in said cells the degradation, inhibition and/or inactivation of BRCA2.

La présente invention porte sur un procédé de traitement ou de prévention d'une maladie hyperproliférative dans un tissu corporel chez un sujet, comprenant les étapes suivantes: administrer à un sujet qui en a besoin une quantité thérapeutiquement efficace d'un agent induisant des ruptures bicaténaires dans l'ADN des cellules hyperprolifératives dudit tissu corporel; et soumettre à une hyperthermie les cellules hyperprolifératives dudit tissu corporel avant, pendant ou après l'étape précédente, pour induire ainsi dans lesdites cellules la dégradation, l'inhibition et l'inactivation de BRCA2.

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