Ribosome structure and protein synthesis inhibitors

Details Ribosome structure and protein synthesis inhibitors Ribosome structure and protein synthesis inhibitors

C - Chemistry, Metallurgy

07

D

C07D 295/24 (2006.01) A61K 31/165 (2006.01) A61K 31/40 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/513 (2006.01) A61K 31/5355 (2006.01) A61K 31/7048 (2006.01) A61K 31/7064 (2006.01) A61K 45/00 (2006.01) A61K 45/06 (2006.01) C07D 239/10 (2006.01) C07G 11/00 (2006.01) C07K 1/00 (2006.01) C07K 14/215 (2006.01) G01N 23/20 (2006.01) G01N 33/68 (2006.01) G06F 17/00 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2391627

The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome- related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

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