Urea and carbamate derivatives as non-nucleoside reverse...

Details Urea and carbamate derivatives as non-nucleoside reverse... Urea and carbamate derivatives as non-nucleoside reverse...

C - Chemistry, Metallurgy

07

D

C07D 235/26 (2006.01) A61K 31/4166 (2006.01) A61P 31/18 (2006.01) C07C 255/54 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2692182

Compounds of formula (I), wherein R 1, R 2, R 3, X and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula (I) useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.

L'invention porte sur des composés représentés par la formule (I), dans laquelle R1, R2, R3, X et Ar sont tels que définis présentement ou sur des sels pharmaceutiquement acceptables de ces composés, lesquels inhibent la transcriptase inverse de HIV-1 et fournissent un procédé pour la prévention et le traitement d'infections par HIV-1 et le traitement du SIDA et/ou de l'ARC. La présente invention porte également sur des compositions contenant des composés de formule (I) utiles pour la prévention et le traitement d'infections par HIV-1 et le traitement du SIDA et/ou de l'ARC.

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