A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 5/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C12N 1/20 (2006.01) C12N 5/12 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2298474
The present invention relates to the mammalian fsh05 gene, a novel gene associated with bipolar affective disorder (BAD) in humans. The invention encompasses fsh05 nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, fsh05 gene products and antibodies directed against such gene products, cloning vectors containing mammalian fsh05 gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of fsh05 and to using such compounds as therapeutic agents in the treatment of fsh05 disorders and neuropsychiatric disorders. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of fsh05 disorders and neuropsychiatric disorders including schizophrenia, attention deficit disorder, a schizoaffective disorder, a bipolar affective disorder or a unipolar affective disorder, and to methods and compositions for the treatment of these disorders.
La présente invention concerne le gène fsh05 de mammifaire, nouveau gène associé au trouble bipolaire affectif (BAD) chez les humains. L'invention concerne des acide nucléïques fsh05, des molécules d'ADN recombinantes, des gènes clonés ou des variantes dégénérées de ceux-ci, des produits du gène fsh05, et des anticorps dirigés contre lesdits produits, des vecteurs de clonage contenant des molécules du gène fsh05 de mammifaire, et des hôtes mis au point par génie génétique, destinés à exprimer lesdites molécules. L'invention concerne également des procédés d'identification des composés qui modulent l'expression de fsh05 et l'utilisation de ces procédés comme agents thérapeutiques dans le traitement de troubles provoqués par fsh05 et de troubles neuropsychiatriques. L'invention concerne, en outre, des procédés d'évaluation de diagnostic, de test génétique et de pronostic de troubles provoqués par fsh05 et de troubles neuropsychiatriques comprenant la schizophrénie, le trouble du déficit de l'attention, le trouble schizoaffectif, le trouble bipolaire affectif ou le trouble unipolaire affectif. L'invention concerne également des procédés et des compositions permettant de traiter ces troubles.
Chen Hong
Freimer Nelson B.
Millenium Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
The Regents Of The University Of California
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