Peptides comprising a t-cell epitope specific to collagen ii

Details Peptides comprising a t-cell epitope specific to collagen ii Peptides comprising a t-cell epitope specific to collagen ii

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/39 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2278638

The invention provides an isolated peptide comprising an amino acid sequence of formula (I): A1-Xaa-Gly-A4-A5-Gly-A7-Xaa-Gly, wherein A1 represents an amino acid residue with an aromatic or aliphatic side chain, A4 represents an asparagine or arginine residue or an amino acid residue with an aromatic or aliphatic side chain, A5 represents any naturally occurring amino acid, A7 represents an amino acid with a negatively charged residue, Xaa represents any amino acid residue, and Gly represents a glycine residue; and the use of such peptides in medical therapy, particularly in the treatment of autoimmune conditions such as rheumotoid arthritis.

L'invention concerne un peptide isolé comprenant une séquence d'acides aminés de la formule (I): A¿1?-Xaa-Gly-A¿4?-A¿5?-Gly-A¿7?-Xaa-Gly, où A¿1? représente un reste d'acide aminé ayant une chaîne latérale aromatique ou aliphatique; A¿4? représente un reste d'asparagine ou d'arginine ou un reste d'acide aminé ayant une chaîne latérale aromatique ou aliphatique; A¿5? représente un acide aminé quelconque naturel; A¿7? représente un acide aminé avec un reste chargé négativement; Xaa représente un reste d'acide aminé quelconque et Gly représente un reste de glycine. L'invention concerne également l'utilisation de tels peptides dans le traitement médical, en particulier dans le traitement d'états autoimmuns tels que la polyarthrite rhumatoïde.

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