Bone stimulating, non-vasoactive parathyroid hormone variants

Details Bone stimulating, non-vasoactive parathyroid hormone variants Bone stimulating, non-vasoactive parathyroid hormone variants

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 38/29 (2006.01) C07K 14/635 (2006.01) C12N 1/21 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2098639

27 ABSTRACT Described herein are Met8-substituted variants of parathyroid hormone that retain bone stimulating activity yet, unlike their native counterparts, have substantially no vasoactivity. Their production using recombinant DNA- based techniques is also described, as is their therapeutic use, e.g. in the treatment of osteoporosis.

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