Oligonucleotides with anti-cytomegalovirus activity

Details Oligonucleotides with anti-cytomegalovirus activity Oligonucleotides with anti-cytomegalovirus activity

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2191191

Disclosed are synthetic oligonucleotides 15 to 50 nucleotides in length which are specifically hybridizable with at least a portion of RNA or DNA derived from the UL36, UL84, UL101x-102, or UL112-113 genes of a cytomegalovirus. Also disclosed are pharmaceutical compositions including an oligonucleotide of the invention and methods of inhibiting cytomegalovirus infection using such oligonucleotides.

La présente invention a pour objet des oligonucléotides, de 15 à 50 nucléotides de long, qui peuvent être hybridés de manière spécifique avec au moins une partie d'ARN ou d'ADN dérivée des gènes UL36, UL84, UL101x-102, ou UL112-113 d'un cytomégalovirus. L'invention traite également de compositions pharmaceutiques comprenant un oligonucléotide selon la présente invention et des procédés pour inhiber l'infection par le cytomégalovirus à l'aide de ces oligonucléotides.

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