Camptothecin derivatives having antitumor activity

Details Camptothecin derivatives having antitumor activity Camptothecin derivatives having antitumor activity

C - Chemistry, Metallurgy

07

D

C07D 491/22 (2006.01) A61K 31/435 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 311/00 (2006.01)

Patent

CA 2362760

Camptothecin derivatives of camptothecin of formula (I), wherein the groups R1, R2 and R3 are as defined in the description are disclosed. The compounds of formula (I) are endowed with antitumor activity and show a good therapeutic index. Processes for the preparation of the compounds of formula (I) and their use in the preparation of medicaments useful in the treatment of tumors, viral infections and antiplasmodium falciparum are also disclosed.

Cette invention concerne des dérivés de camptothécine qui correspondent à la formule (I) où les groupes R1, R2 et R3 sont tels que définis dans la description. Ces composés possèdent une action antitumorale et font preuve d'un bon indice thérapeutique. Cette invention concerne également des procédés de préparation des composés correspondant à la formule (I), ainsi que leur utilisation dans la fabrication de médicaments permettant de traiter des tumeurs, des infections virales, ainsi que l'antiplasmodium falciparum.

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