A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 9/00 (2006.01) A61K 47/34 (2006.01) A61K 38/08 (2006.01) A61K 38/22 (2006.01) A61K 38/26 (2006.01) A61K 38/28 (2006.01)
Patent
CA 2657911
The present invention provides methods of forming a solid, biodegradable implant in-situ in a body by administering a liquid pharmaceutical composition comprising an effective amount of a biocompatible, water-insoluble, biodegradable polymer and an effective amount of a therapeutic peptide covalently modified with one or more lipophilic or amphiphilic moieties, which are dissolved or dispersed in a biocompatible, water-soluble organic solvent. This invention also provides related compositions and methods.
La présente invention concerne des procédés de formation d'un implant solide et biodégradable in situ dans un corps par administration d'une composition pharmaceutique liquide comprenant une quantité efficace d'un polymère biocompatible, insoluble dans l'eau et biodégradable et une quantité efficace d'un peptide thérapeutique modifié de manière covalente par une ou plusieurs fonctions lipophiles ou amphiphiles, qui sont dissous ou dispersés dans un solvant organique biocompatible et soluble dans l'eau. L'invention concerne également les compositions et procédés associés.
Chien Benjamin
Li Yuhua
Moffat & Co.
Qps Llc
Quest Pharmaceutical Services Llc
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