Method of preparation of dtpa crosslinked hyaluronic acid...

Details Method of preparation of dtpa crosslinked hyaluronic acid... Method of preparation of dtpa crosslinked hyaluronic acid...

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01)

Patent

CA 2742428

The invention relates to the modification of hyaluronic acid by means of a protonized DTPA bis anhydride in a non-basic polar aprotic solvent in absence of any external base to form crosslinked products. The reaction runs via the formation of a complex and the acylating agent is the hyaluronan co-cation itself, i.e. protonized DTPA bis anhydride. The final crosslinked derivative (linker) comprises three carboxylic groups and three tertiary amines which are capable of complexing various metals effectively. The final DTPA crosslinked hyaluronic acid may also be hydrophobized by means of mono, bis or tris functional alkylating agents.

L'invention porte sur la modification de l'acide hyaluronique au moyen d'un bisanhydride de DTPA protoné dans un solvant aprotique polaire non basique en l'absence de toute base externe pour former des produits réticulés. La réaction se déroule par l'intermédiaire de la formation d'un complexe et l'agent d'acylation est le cocation hyaluronane lui-même, c'est-à-dire le bisanhydride de DTPA protoné. Le dérivé réticulé final (groupe de liaison) comprend trois groupes carboxyliques et trois amines tertiaires qui sont aptes à complexer divers métaux de manière efficace. L'acide hyaluronique réticulé par du DTPA final peut également être rendu hydrophobe au moyen d'agents d'alkylation monofonctionnels, bifonctionnels ou trifonctionnels.

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