C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/22 (2006.01) C12N 9/10 (2006.01) C12Q 1/25 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/542 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2373744
A polynucleotide motor is disclosed, comprising an enzyme capable of binding to a nucleic acid sequence, which enzyme is also capable of translocating the nucleic acid sequence without causing cleavage thereof. The motor may be associated with a substance bound to the nucleic acid sequence so that the bound substance, such as a magnetic bead, biotin, streptavidin, a scintillant or the like, can itself be translocated, relative to the region of binding of the enzyme, during translocation. Such a system has applications in the screening or testing for a pre-determined biological, chemical or physical activity; for example, in screening for new pharmacologically-effective ligands.
La présente invention concerne un moteur polynucléotidique comprenant un enzyme capable de se lier à une séquence nucléotidique, et capable également de transloquer ladite séquence nucléotidique sans provoquer son clivage. Le moteur de l'invention peut être associé à une substance liée à la séquence nucléotidique de façon que la substance liée, telle une bille magnétique, de la biotine, de la streptavidine, une substance scintillante ou analogue, peut elle-même être transloquée par rapport à la région de liaison de l'enzyme au cours de la translocation. Le système de l'invention trouve des applications dans le criblage ou l'épreuve à la recherche d'une activité biologique, chimique ou physique prédéterminée, par exemple dans le criblage de nouveaux ligands pharmacologiquement efficaces.
Btg International Limited
Fetherstonhaugh & Co.
The University Of Portsmouth
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