C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 251/44 (2006.01) A61K 31/53 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 251/46 (2006.01) C07D 251/48 (2006.01) C07D 251/50 (2006.01) C07D 251/52 (2006.01) C07D 251/70 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 453/02 (2006.01)
Patent
CA 2461074
The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
La présente invention concerne des méthodes et des compositions faisant intervenir des composés destinés au traitement d'états pathophysiologiques générés par des réponses inflammatoires. La présente invention concerne, en particulier, des composés inhibant ou bloquant l'induction produite par des protéines glyquées de réponses inflammatoires associées à la signalisation dans les cellules endothéliales. La présente invention concerne des composés inhibant la prolifération du muscle lisse. La présente invention concerne, en particulier, des composés inhibant la prolifération des cellules du muscle lisse par modulation des HSPG, tels que le perlecan. La présente invention concerne également l'utilisation de composés destinés au traitement de vasculopathies occlusives caractérisées par une prolifération du muscle lisse, tels que la resténose et l'athérosclérose.
Alexander Christopher W.
Campbell Karen A.
Pillarisetti Sivaram
Saxena Uday
Timmer Richard T.
Finlayson & Singlehurst
Reddy Us Therapeutics Inc.
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