Mediation of cytokines by melanin

A - Human Necessities – 61 – K

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Details

A61K 31/195 (2006.01) A61K 31/00 (2006.01) A61K 31/40 (2006.01) A61K 31/785 (2006.01)

Patent

CA 2279946

Methods and compositions are provided that teach the use of purified melanin compositions to treat, prevent, or ameliorate diseases that are associated with excess cytokine production. In particular, methods and compositions are provided that are useful in reducing the cellular production and release of the cytokine TNF-.alpha., and the adverse disease consequences associated therewith.

La présente invention concerne des procédés et l'utilisation de compositions de mélanine purifiée en vue de traiter, d'empêcher des maladies ou d'améliorer un état lié à ces maladies qui sont associées à la production excédentaire de cytokines. En particulier, l'invention concerne des procédés et compositions qui sont utiles à la réduction, d'une part, de la production et de la libération cellulaire de la cytokine TNF-.alpha. et, d'autre part, des conséquences négatives pathologiques qui y sont associées.

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