Mag derivatives, compositions, and methods of use thereof

Details Mag derivatives, compositions, and methods of use thereof Mag derivatives, compositions, and methods of use thereof

A - Human Necessities

61

K

A61K 38/00 (2006.01) C07K 14/00 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2510297

The present invention relates generally to products, compositions and methods useful for promoting neural repair and regeneration. The products and compositions of this invention include myelin-associated glycoprotein (MAG) derivatives that are inhibitors of endogenous MAG (e.g., mutant MAG proteins) and Nogo Receptor (NgR) binding inhibitors that are peptides derived from MAG, Nogo and OM that can bind to NgR and block NgR signaling. Peptides that can bind and activate NgR signaling are also provided. Inhibitory MAG derivatives and NgR binding inhibitors are useful for blocking the inhibition of neural regeneration mediated by proteins such as MAG, Nogo and/or OMgp in the nervous system. These inhibitors are also useful for treating neural degeneration associated with injuries, disorders or diseases.

L'invention concerne, de manière générale, des produits, des compositions et des procédés utiles dans l'activation de la régénération et de la réparation neurales. Les produits et les compositions de cette invention contiennent des dérivés de glycoprotéine associée à la myéline (MAG) qui sont des inhibiteurs de la MAG endogène (par exemple, des protéines MAG mutantes) et des inhibiteurs de liaison du récepteur Nogo (NgR) qui sont des peptides dérivés de la MAG, de Nogo et OMgp pouvant se lier à NgR et bloquer la signalisation de NgR. L'invention concerne également des peptides pouvant se lier et activer la signalisation de NgR. Des dérivés de MAG inhibiteurs et des inhibiteurs de liaison de NgR sont utiles dans le blocage de l'inhibition de la régénération neurale induite par les protéines telles que MAG, Nogo et/ou OMgp dans le système nerveux. Ces inhibiteurs sont également utiles dans le traitement de la dégénération neurale associée aux blessures, troubles ou maladies.

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