Compositions that bind antiterminator rna and their assays

Details Compositions that bind antiterminator rna and their assays Compositions that bind antiterminator rna and their assays

C - Chemistry, Metallurgy

07

D

C07D 263/20 (2006.01) A61K 31/421 (2006.01) A61L 2/16 (2006.01) C07C 215/10 (2006.01) C07C 215/20 (2006.01) C07C 215/28 (2006.01) C07C 217/64 (2006.01) C07D 263/24 (2006.01) C12Q 1/68 (2006.01) G01N 21/64 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2458507

Compounds that are selective binding agents specific for RNA secondary and tertiary structures and a fluorescence assay for detecting the binding of small molecules to T-box antiterminator model mRNAs. The compounds include novel tri-substituted oxazolidinones and amino alcohols. The assay provides fluorescently labelled model mRNAs that include conserved sequence information typical of antiterminator bulge regions found in the mRNA of T-box gene regulatory systems.

La présente invention concerne des composés qui sont des agents de liaison sélectifs spécifiquement destinés à des structures secondaires et tertiaires d'ARN et un dosage par fluorescence permettant de détecter la liaison de petites molécules à des ARNm modèles d'antiterminateur de boîte T. Ces composés comprennent de nouvelles oxazolidinones tri-substituées et de nouveaux amino-alcools. Le dosage utilise des ARNm modèles marqués par fluorescence qui comprennent des informations de séquences conservées propres aux régions de bosse d'antiterminateur qui ont été trouvées dans l'ARNm des systèmes de régulation des gènes à boîte T.

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