4-ring imidazole derivatives as modulators of metabotropic...

Details 4-ring imidazole derivatives as modulators of metabotropic... 4-ring imidazole derivatives as modulators of metabotropic...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01)

Patent

CA 2520863

Imidazole compounds of Formula (I): (where A, B, R11, R12, W, X. Y and Z are as defined herein) wherein the imidazole is substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring, with at least one of the rings being further substituted with another ring, which are MgluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson~s disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders - such as shift- work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal, obesity and other diseases, and pharmaceutical compositions and methods of treating these diseases.

L'invention concerne des composés d'imidazole de formule générale (I) (dans laquelle A, B, R¿11?, R¿12?, W, X. Y et Z ont la signification indiquée dans la description) dans lesquels l'imidazole est substitué directement, ou par un pont, par i) un fragment hétéroaryle contenant N adjacent au point de connexion de l'hétéroaryle et ii) un autre cycle hétéroaryle ou aryle, au moins un des cycles étant en outre substitué par un autre cycle. Ces composés sont des modulateurs MgluR5 utiles dans le traitement de troubles psychiatriques et de l'humeur, de type schizophrénie, anxiété, dépression, troubles bipolaires, et panique; ainsi que dans le traitement de la douleur, la maladie de Parkinson, le dysfonctionnement cognitif, l'épilepsie, les troubles du rythme circadien et du sommeil, par exemple les troubles du sommeil provoqués par le travail par postes et le décalage horaire, la toxicomanie, l'abus de drogues, le sevrage de drogues, l'obésité et d'autres maladies. L'invention concerne également des compositions pharmaceutiques ainsi que des procédés de traitement des maladies mentionnées.

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