Method and nucleic acids for the analysis of colon cancer

Details Method and nucleic acids for the analysis of colon cancer Method and nucleic acids for the analysis of colon cancer

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2455161

The present invention relates to chemically modified genomic sequences, oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to methods for ascertaining genetic and/or epigenetic parameters of genes for use in the characterisation, grading, staging, and/or diagnosis of colon cancer, or the predisposition to colon cancer.

L'invention se rapporte à des séquences de génomes modifiées chimiquement, à des oligonucléotides et/ou à des oligopolymères PNA permettant de détecter la méthylation de cytosine d'ADN génomique, et à des procédés d'identification de paramètres génétiques et/ou épignénétiques de gènes à utiliser dans la caractérisation, l'histopronostic, la stadification et/ou le diagnostic du cancer du colon, ou la prédisposition au cancer du colon.

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