C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 519/00 (2006.01) A61K 31/55 (2006.01) A61P 25/06 (2006.01) C07D 487/04 (2006.01) C07D 487/14 (2006.01)
Patent
CA 2711367
Compounds of Formula I: I (where variables R1A, R1B, R2, R3, R4, A, and Z are as defined herein) useful as antago-nists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions compris-ing these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.
L'invention concerne des composés de formule I : I (dans laquelle les variables R1A, R1B, R2, R3, R4, A, et Z sont définies ici) utiles comme antagonistes de récepteurs de CGRP et utiles dans le traitement ou la prévention de maladies dans lesquelles les récepteurs de CGRP sont impliqués, comme les maux de tête, et en particulier la migraine et l'algie vasculaire de la face. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et compositions dans la prévention et le traitement de maladies dans lesquelles sont impliqués les récepteurs de CGRP.
Bell Ian M.
Selnick Harold G.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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