New pyridone derivatives with mch antagonistic activity and...

Details New pyridone derivatives with mch antagonistic activity and... New pyridone derivatives with mch antagonistic activity and...

C - Chemistry, Metallurgy

07

D

C07D 401/10 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 403/10 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 409/14 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2657183

The present invention relates to compounds of general formula (I) wherein the groups and radicals B, k, L, U,V, W, X, Y, Z, R1, R2, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH- receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

L'invention concerne des composés représentés par la formule générale (I), dans laquelle les groupes et radicaux B, k, L, U, V, W, X, Y, Z, R1, R2 ont les significations données dans la revendication 1. De plus, l'invention concerne des compositions pharmaceutiques contenant au moins un composé selon l'invention. Grâce à leur activité antagoniste du récepteur MCH, les compositions pharmaceutiques décrites dans la présente invention sont appropriées pour le traitement de troubles métaboliques et/ou de troubles de l'alimentation, en particulier de l'obésité, de la boulimie, de l'anorexie, de l'hyperphagie et du diabète.

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