Tablet shapes to enhance gastric retention of swellable...

Details Tablet shapes to enhance gastric retention of swellable... Tablet shapes to enhance gastric retention of swellable...

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2412671

The retention of oral drug dosage forms in the stomach is improved by using swellable dosage forms that are shaped in a manner that will prevent them from inadvertently passing through the pylorus as a result of being in a particular orientation. The planar projection of the shape is one that has two orthogonal axes of different lengths, the longer being short enough to permit easy swallowing prior to swelling while the shorter is long enough within one-half hour of swelling to prevent passage through the pylorus.

Selon l'invention, pour accroître la rétention des formes posologiques orales dans l'estomac, on utilise des formes posologiques gonflantes configurées de manière à ne pas pouvoir passer par inadvertance dans le pylore du fait qu'elles se trouvent dans une orientation particulière. En projection planaire, lesdits formes possèdent deux axes orthogonaux de longueurs différentes, le plus long étant suffisamment court pour être avalé sans encombre avant qu'il ne gonfle, le plus court étant suffisamment long pour empêcher tout passage dans le pylore dans la demi-heure suivant le gonflement.

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