C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 35/00 (2006.01) A61K 48/00 (2006.01) C07K 14/15 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2285667
The invention involves viral vectors that can be used to transduce a target cell, i.e., to introduce genetic material into the cell. The targets of interest are eukaryotic cells and particularly human cells. The transduction can be done in vivo or in vitro. More particularly the invention concerns viral vectors that have chimeric enveloppe proteins and contain the IgG-binding domain of protein A. These vectors when used in conjunction with antibodies targeting a particular cell are particularly useful for gene therapy.
L'invention a trait à des vecteurs viraux pouvant être utilisés aux fins de la transduction d'une cellule cible, c'est à dire, de l'introduction de matériel génétique dans la cellule. Les cibles concernées sont des cellules eucaryotes et, notamment, des cellules humaines. La transduction peut être effectuée in vivo ou in vitro. Cette invention porte, plus particulièrement, sur des vecteurs viraux pourvus de protéines chimère enveloppe et renfermant le domaine de fixation d'IgG de la protéine A. Utilisés de concert avec des anticorps ciblant une cellule particulière, ces vecteurs se révèlent des plus utiles en matière de thérapie génique.
Meruelo Daniel
Ohno Kouichi
New York University
Osler Hoskin & Harcourt Llp
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