Display phage

Details Display phage Display phage

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) C07K 1/00 (2006.01) C07K 1/107 (2006.01) C07K 14/005 (2006.01) C07K 14/435 (2006.01) C12N 7/00 (2006.01) C12N 15/09 (2006.01) C12N 15/10 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12N 15/66 (2006.01) C12N 15/70 (2006.01) C12P 21/00 (2006.01) C12P 21/02 (2006.01) C12Q 1/70 (2006.01) G01N 33/53 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2105303

2105303 9215679 PCTABS00016 The present invention relates to libraries of display phage which display various mutant epitopic peptides or protein domains with potential to bind to a target material of interest. Site-specific protease cleavable linkers may be incorporated into these phages to overcome the problem of irreversible binding to target materials. When the displayed insert is a mini-protein, a reagent which cleaves the crosslink may be used to facilitate release of a tightly bound display phage. The invention also relates to providing a more balanced library of epitopic peptide display phage.

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