C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 339/02 (2006.01) A61K 31/385 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2477254
Disclosed are methods for treating obstructive and ischemic bladder diseases which include administering a compound which includes a cyclic or acyclic disulfide covalently bonded to a lipid-soluble antioxidant or which include administering a reduced sulfhydryl derivative thereof. Also disclosed are compounds that include a benzopyran moiety which is directly or indirectly covalently bonded to a cyclic or acyclic disulfide, as well as reduced sulfhydryl derivatives of such compounds. Methods for making such compounds and reduced sulfhydryl derivatives using tocopherol and lipoic acid starting materials are also disclosed, as are methods for inhibiting oxidative and/or free radical damage in a subject's cells, nerve membranes, sarcoplasmic reticula, mitochondrial membranes, and/or muscle plasma membranes and methods for treating and/or preventing obstructive and ischemic bladder diseases, conditions involving hypoxia, ischemia, and/or reoxygenation injury.
L'invention concerne des méthodes de traitement de maladies obstructives et ischémiques de la vessie qui consistent à administrer un composé comprenant un disulfure cyclique ou acyclique lié par covalence à un antioxydant liposoluble ou qui consiste à administrer un dérivé sulfhydryle réduit de ce composé. L'invention concerne aussi des composés comprenant un groupe benzopyrane, directement ou indirectement lié par covalence à un disulfure cyclique ou acyclique, ainsi que des dérivés sulfhydryle réduits de tels composés. Elle concerne encore des procédés de fabrication de ces composés et des dérivés sulfhydryle réduits au moyen de tocophérol et d'acide lipoïque en tant que matières premières, ainsi que des méthodes d'inhibition dirigées contre les agressions oxydantes et/ou radicalaires dans les cellules, les membranes nerveuses, le réticulum sarcoplasmique, les membranes mitochondriales, et/ou les membranes plasmiques musculaires d'un sujet ainsi que des méthodes de traitement et/ou de prévention de maladies obstructives et ischémiques de la vessie, de troubles impliquant une hypoxie, une ischémie et/ou un dommage par réoxygénation.
Hass Martha A.
Levin Robert M.
Albany College Of Pharmacy
Bereskin & Parr
LandOfFree
Methods and compounds useful in inhibiting oxidative and/or... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compounds useful in inhibiting oxidative and/or..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compounds useful in inhibiting oxidative and/or... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1891943