Identifying agents that alter mitochondrial permeability...

Details Identifying agents that alter mitochondrial permeability... Identifying agents that alter mitochondrial permeability...

A - Human Necessities

61

K

A61K 31/155 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2345066

The invention is directed to methods for identifying agents that affect mitochondrial functions and cell death. Such agents are useful for treating diseases associated with mitochondrial dysfunction and to methods of identifying a risk or presence of such diseases. In particular, the invention relates to the loss of mitochondrial membrane potential (.DELTA.~m) during mitochondrial permeability transition (MPT) and further provides a measurable rate loss function, changes in which are useful, inter alia, for detecting agents that affect one or more mitochondrial functions, for detecting mitochondrial diseases and for studying molecular components of mitochondria that regulate MPT.

L'invention concerne des techniques d'identification d'agents ayant une incidence sur les fonctions et la mort cellulaire des mitochondries. Ces agents sont utiles dans le traitement de maladies associées à un dysfonctionnement des mitochondries. L'invention concerne également des techniques d'identification d'un risque ou de la présence de ces maladies. L'invention concerne, en particulier, la diminution du potentiel de la membrane mitochondriale (.DELTA.~m) lors de la transition de perméabilité des mitochondries (MPT), diminution qui se traduit par une fonction de perte mesurable, dont les changements sont utiles, entre autres, pour la détection des agents ayant une incidence sur une ou plusieurs fonctions des mitochondries, pour la détection de maladies mitochondriales et pour l'étude des composants moléculaires des mitochondries régulant la MPT.

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