Heterocyclyl-substituted anti-hypercholesterolemic compounds

Details Heterocyclyl-substituted anti-hypercholesterolemic compounds Heterocyclyl-substituted anti-hypercholesterolemic compounds

C - Chemistry, Metallurgy

07

D

C07D 417/10 (2006.01) A61K 31/4178 (2006.01) A61K 31/4192 (2006.01) A61K 31/4196 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/495 (2006.01) A61K 31/497 (2006.01) A61K 31/541 (2006.01) A61P 9/10 (2006.01) C07D 403/10 (2006.01) C07D 413/10 (2006.01)

Patent

CA 2668371

This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R12 is a hydroxylated alkyl group and R9 contains a heterocyclic ring. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.

L'invention concerne des inhibiteurs de l'absorption du cholestérol de formule I : et ses sels pharmaceutiquement acceptables, R12 représentant un groupement alkyle hydroxylé et R9 contenant un cycle hétérocyclique. Les composés sont utiles pour l'abaissement des niveaux de cholestérol, notamment de cholestérol LDL, et pour le traitement de l'athérosclérose et la prévention des évènements athérosclérotiques.

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