Starch derivatives, starch active-substance conjugates,...

Details Starch derivatives, starch active-substance conjugates,... Starch derivatives, starch active-substance conjugates,...

C - Chemistry, Metallurgy

08

B

C08B 31/00 (2006.01) A61K 31/718 (2006.01) A61K 47/36 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2473068

The invention relates to starch derivatives of formula (I), in which: X represents a bromine or iodine atom; R" represents a straight-chain or branched alkyl group, aryl group or aralkyl group, and; R-CO- represents an oxidized substituted or unsubstituted starch radical that is oxidized on the reducing terminal group to form a carboxylic acid. Starch derivatives of formula (I) can selectively couple to active substances containing SH groups and have a prolonged half-life period in the human body. The invention also relates to coupling products of compound (I) with active substances, to methods for the production thereof, and to their use as medicaments.

L'invention concerne des dérivés d'amidon de formule (I), dans laquelle X représente un atome de brome ou d'iode, R" un groupe alkyle, aryle ou aralkyle linéaire ou ramifié et R-CO- un groupe amidon oxydé substitué ou non substitué qui est oxydé au niveau du groupe terminal réducteur en un acide carboxylique. Les dérivés d'amidon de formule (I) peuvent être couplés de façon sélective à des substances actives contenant des groupes SH et ils possèdent une période de demi-vie prolongée dans le corps humain. L'invention concerne en outre des produits de couplage du composé (I) avec des substances actives, des procédés de production de ces produits et leur utilisation en tant que médicaments.

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