C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 243/04 (2006.01) A61P 3/04 (2006.01) C07D 211/76 (2006.01) C07D 265/10 (2006.01)
Patent
CA 2715290
This invention relates to novel compounds of the Formula (I), any of the formulas I1-I26 1a1-3-1j1-3 or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11.beta.-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
L'invention concerne de nouveaux composés représentés par la formule (I), toute formule parmi les formules I1-I26 Ia1-3-lj1-3 ou leurs sels acceptables sur le plan pharmaceutique, ainsi que leurs compositions pharmaceutiques, utiles pour le traitement de maladies associées à la modulation ou à l'inhibition de 11 ß-HSD1 chez des mammifères. L'invention concerne également des compositions pharmaceutiques contenant ces nouveaux composés et leurs procédés d'utilisation afin de diminuer ou de contrôler la production de Cortisol dans une cellule ou d'inhiber la conversion de cortisone en Cortisol dans une cellule.
Claremon David A.
Simpson Robert D.
Singh Suresh B.
Tice Colin M.
Ye Yuanjie
Gowling Lafleur Henderson Llp
Vitae Pharmaceuticals Inc.
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