C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2591817
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds which act as ligands for the .alpha.7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
L'invention concerne de façon générale le champ des ligands pour des récepteurs acétylcholines nicotiniques (nAChR), l'activation des nAChR, et le traitement d'états pathologiques associés à des récepteurs acétylcholines nicotiniques défectueux ou défaillants, plus spécialement ceux du cerveau. En outre, l'invention concerne de nouveaux composés qui agissent en tant que ligands pour le sous-type a7 nAChR, des procédés de préparation de tels composés, des compositions contenant de tels composés ainsi que des procédés d'utilisation associés.
Herbert Brian
Nguyen Truc Minh
Schumacher Richard
Tehim Ashok
Xie Wenge
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Memory Pharmaceuticals Corporation
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