Estrogenic extracts of morus alba and uses thereof

Details Estrogenic extracts of morus alba and uses thereof Estrogenic extracts of morus alba and uses thereof

A - Human Necessities

61

K

A61K 36/605 (2006.01) A61P 9/00 (2006.01) A61P 15/12 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12N 15/113 (2010.01) C12N 15/85 (2006.01)

Patent

CA 2588566

Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Morus alba L. species possess estrogenic properties in both ER.alpha.+ and ER.beta.+ cells. These estrogenic effect include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.

L'invention concerne des extraits de diverses espèces de la famille des moracées qui possèdent des propriétés oestrogéniques, tels que, par exemple, des extraits aqueux et éthanoliques de Morus alba L., dont les cellules ER.alpha.+ et ERß+ possèdent des propriétés oestrogéniques. L'action oestrogénique de ces extraits comprend la stimulation des éléments de réponse oestrogénique (ERE) et la répression du facteur de nécrose des tumeurs (TNF). L'invention concerne des méthodes de traitement des symptômes du climatère, du cancer du sein et/ou de l'utérus, et de l'ostéoporose.

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