Biocompatible substrate with a surface to which cells have a...

A - Human Necessities – 61 – F

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A61F 2/00 (2006.01) A61L 27/34 (2006.01) A61L 27/58 (2006.01) A61F 2/08 (2006.01)

Patent

CA 2322456

A biocompatible substrate for use as a resorbable or non-resorbable implant, graft, prosthesis, etc., has an array of pro-jections or pits of nanometer dimensions on a surface thereof, which resist attachment of cells. Typically the projections or pits are 10-250 nm in size and at spacings of 20-500 nm. The substrate may additionally have areas where cell adhesion is promoted.

La présente invention concerne un substrat biocompatible pouvant être utilisé, entre autres, comme implant, greffon, prothèse résorbable ou non résorbable. Ledit substrat comprend, sur l'une de ses surfaces, un réseau de protubérances ou de puits de dimensions nanométriques empêchant l'adhésion des cellules. En général, les protubérances ou les puits mesurent de 10 à 250 nm et ils sont espacés par des distances de 20 à 500 nm. Le substrat de l'invention peut en outre comprendre des zones qui favorisent l'adhésion cellulaire.

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