Use of phospholamban inhibitors for increasing coronary flow

Details Use of phospholamban inhibitors for increasing coronary flow Use of phospholamban inhibitors for increasing coronary flow

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/00 (2006.01) A61K 31/41 (2006.01) A61K 31/47 (2006.01) C07D 215/227 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2294550

A method for obtaining direct dilatation of the coronary arteries by administering a therapeutically effective amount of a phospholamban inhibitor is described. Compounds which are effective in relieving the inhibitory effects of phospholamban on cardiac sarcoplasmic reticulum Ca2+-ATPase are also described.

L'invention concerne un procédé permettant d'obtenir une dilatation directe des artères coronaires grâce à l'administration d'une quantité thérapeutiquement efficace d'un inhibiteur de phospholamban. L'invention concerne également des composés permettant de soulager efficacement les effets inhibiteurs du phospholamban sur la Ca?2+¿-ATPase du réticulum sarcoplasmique.

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