A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/5377 (2006.01) C12N 5/076 (2010.01) A01N 1/02 (2006.01) A61K 31/352 (2006.01) A61K 31/585 (2006.01) A61K 35/52 (2006.01) A61P 15/08 (2006.01) B03B 7/00 (2006.01)
Patent
CA 2378650
The invention relates to a process for the improvement of spermatozoa fertilization activity, in particular for the increase of spermatozoa motility by inhibiting the enzyme phosphatidylinositol-3 kinase (PI3K). The invention further relates to uses and methods of PI3K inhibitors in infertility and assisted reproduction techniques (ART) as well as to a medium for storage and/or transportation of spermatozoa comprising PI3K inhibitors. The PI3K inhibitors are selected from the group consisting of 2-(4-morpholinyl)-8- phenyl-4H-1-benzopyran-4-one (LY294002), wortmannin, quercetin, and derivatives and analogues thereof.
L'invention concerne un processus destiné à améliorer l'activité de fécondation des spermatozoïdes et notamment à augmenter la motilité des spermatozoïdes par l'inhibition de l'enzyme phosphatidylinositol-3 kinase (PI3K). En outre, l'invention concerne des procédés d'utilisation des inhibiteurs de PI3K dans le traitement de l'infécondité et dans des techniques de reproduction assistée (TRA), ainsi qu'un milieu pour stocker et/ou transporter les spermatozoïdes qui comprend des inhibiteurs de PI3K. Les inhibiteurs de PI3K sont sélectionnés dans le groupe constitué de 2-(4-morpholinyl)-8-phényl-4H-1-benzopyran-4-one (LY294002), de wortmannine, de quercétine ainsi que de leurs dérivés et analogues.
Baldi Elisabetta
Forti Gianni
Luconi Michaela
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
LandOfFree
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