C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/4178 (2006.01) A61P 13/00 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2523253
This invention relates to compounds which are alpha- 1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula (I), wherein m, A, X, Y, R1, R2, R3, R4 and R5 are as defined in the specification; or individual isomers, racemic or non~racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
L'invention concerne des composés servant d'agonistes du récepteur alpha-1, de préférence d'agonistes du récepteur alpha-1A/L, représentés par la formule (I) dans laquelle m, A, X, Y, R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ ont les significations données dans le descriptif, ou des isomères individuels, des mélanges d'isomères racémiques ou non racémiques, ou des sels ou solvates pharmaceutiquement acceptables de ces composés. L'invention concerne par ailleurs des compositions pharmaceutiques contenant de tels composés, des procédés d'utilisation de ces compositions en tant qu'agents thérapeutiques et des procédés de préparation de celles-ci.
Dillon Michael Patrick
Lin Clara Jeou Jen
Moore Amy Geraldine
O'yang Counde
Zhai Yansheng
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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