Anticancer compound and enantiomer separation method useful...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 401/14 (2006.01) C07B 57/00 (2006.01)

Patent

CA 2586175

The present invention relates to the compound (+)-6-[amino-(6-chloro-pyridin- 3yl)-(3-methyl- 3H-imidazol-4-yl)-methyl]-4-(3 -chloro-phenyl)-1-cyclopropylmethyl-1H-quinolin- 2-one, pharmaceutically acceptable salts and solvates thereof, prodrugs thereof, and to the use of said compound for inhibiting abnormal cell growth, including cancer, in mammals. The invention also relates to methods useful in synthesizing the aforementioned compound.

La présente invention porte sur le composé (+)-6-¬amino-(6-chloro-pyridin-3yl)-(3-méthyl- 3H-imidazol-4-yl)-méthyl|-4-(3-chloro-phényl)-1-cyclopropylméthyl-1H-quinolin-2-one, les sels et les solvates pharmaceutiquement acceptables de celui-ci, les promédicaments de celui-ci et l'utilisation dudit composé pour inhiber la prolifération cellulaire anormale, y compris le cancer, chez les mammifères. L'invention concerne également les méthodes utiles pour synthétiser le composé susmentionné.

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