Synthesis of (r) and (s)-aminocarnitine and derivatives...

C - Chemistry – Metallurgy – 07 – C

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C07C 227/18 (2006.01) A61K 31/662 (2006.01) C07C 227/14 (2006.01) C07F 9/54 (2006.01) C07C 229/26 (2006.01)

Patent

CA 2512679

A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the above formula (I), where Y is as described in the attached description, starting from aspartic acid with the same configuration as the desired compounds. This process is advantageous from the industrial point of view in terms of the type of reactants used, the reduced volumes of solvents and the possibility of avoiding purification of the intermediate products.

L'invention concerne un procédé permettant de préparer de l'aminocarnitine R ou S, du phosphonium aminocarnitine R ou S et de l'acide R et S 3,4 diaminobutanoïque et des dérivés de ceux-ci de formule susmentionnée (I), dans laquelle Y est décrit dans la description jointe, à partir de l'acide aspartique ayant la même configuration que les composés souhaités. Ce procédé présente un caractère avantageux d'un point de vue industriel au niveau du type de réactifs utilisés, des volumes réduits de solvants et du fait qu'il est possible d'éviter une purification des produits intermédiaires.

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