A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2311182
The present invention provides compositions with high affinity for a target transcription factor, that can be introduced into cells as decoy cis-elements to bind the factor and alter gene expression. Specifically, the present invention provides nucleic acid molecules that complete with cAMP response element (CRE) enhancers for binding to transcription factors.
La présente invention concerne des compositions présentant une grande affinité pour un facteur de transcription cible, pouvant être introduites dans des cellules sous forme d'éléments cis-leurre afin de se lier au facteur et modifier l'expression du gène. L'invention concerne, en particulier, des molécules d'acide nucléique entrant en compétition avec les activateurs de l'élément de réponse de cAMP pour lier les facteurs de transcription.
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Smart & Biggar
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