Topical formulations containing o-desmethyl venlafaxine...

Details Topical formulations containing o-desmethyl venlafaxine... Topical formulations containing o-desmethyl venlafaxine...

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 9/00 (2006.01) A61P 15/12 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2620164

The present invention provides topical compositions comprising O- desmethylvenlafaxine (ODV), a selective serotonin and norepinephrine re-uptake inhibitor, or a pharmaceutically acceptable salt thereof. In certain embodiments, the inventive topical formulations contain one or more percutaneous/permucosal absorption enhancers. Also provided are methods of preparing and using these compositions for the treatment of various diseases or conditions such as vasomotor symptoms and pain.

La présente invention propose des compositions topiques comprenant un O-desméthylvenlafaxine (ODV), une sérotonine sélective et un inhibiteur de la réingestion de norépinéphrine ou un sel dérivé pharmaceutiquement acceptable. Dans certains modes de réalisation, les formulations topiques inventives contiennent un ou plusieurs éléments d~amélioration de l~absorption percutanée/permuqueuse. Sont également fournis des procédés de préparation et d~utilisation de ces compositions pour le traitement de diverses maladies ou conditions telles que des symptômes vasomoteurs et une douleur.

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