Piperidine derivatives and their use as tachykinin antagonists

Details Piperidine derivatives and their use as tachykinin antagonists Piperidine derivatives and their use as tachykinin antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/445 (2006.01)

Patent

CA 2309162

Substituted piperidine derivatives of structural formula (I), wherein R1 represents a hydrogen atom or a methyl or trifluoromethyl group; R2 represents a hydrogen or halogen atom; and R3 represents a hydrogen or halogen atom; and pharmaceutically acceptable salts thereof are tachykinin receptor antagonists of use, for example, in the treatment or prevention of pain, inflammation, migraine, emesis, postherpetic neuralgia, depression and anxiety.

L'invention concerne des dérivés de pipéridine représentés par la formule développée (I) dans laquelle R?1¿ représente un atome d'hydrogène ou un groupe méthyle ou trifluorométhyle; R?2¿ représente un atome d'hydrogène ou d'halogène; et R?3¿ représente un atome d'hydrogène ou d'halogène; ainsi que les sels pharmaceutiquement acceptables de ces derniers. Ces dérivés sont des antagonistes des récepteurs de tachykinine, utiles par exemple dans le traitement ou la prévention des douleurs, des inflammations, de la migraine, des vomissements, des algies post-zostériennes, de la dépression et de l'anxiété.

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