Methods for treating diseases using oxidized lipoproteins

Details Methods for treating diseases using oxidized lipoproteins Methods for treating diseases using oxidized lipoproteins

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) A61K 35/14 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/44 (2006.01) A61M 1/36 (2006.01) C07K 14/775 (2006.01)

Patent

CA 2067356

2067356 9104744 PCTABS00003 The present invention relates to treating disease states in a living patient using oxidized lipoproteins, preferably low density peroxidized lipoproteins. Methods and apparatus are provided for preparing the oxidized lipoproteins. It has been discovered that diseased cells, characterized by an increased number of lipoprotein receptors or an enhanced ability to take up lipoproteins are more susceptible than healthy cells to the cytotoxic effect of oxidized lipoproteins. Oxidized lipoproteins are used to treat disease states such as cancer, malaria and viral infections such as acquired immunodeficiency syndrome (AIDS). Proton and carbon-13 NMR spectroscopy is used to measure the degree and effect of treatment with oxidized lipoproteins.

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