Process for making phenylthiomethylpyridinylalkenoates

Details Process for making phenylthiomethylpyridinylalkenoates Process for making phenylthiomethylpyridinylalkenoates

C - Chemistry, Metallurgy

07

D

C07D 213/65 (2006.01) C07D 213/55 (2006.01) C07D 213/89 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2138955

This invention relates to a process of making a compound of formula (I) where R1 contains an .alpha.,.beta.-unsaturated carbonyl group and Rn is hydrogen or nonhydrogen radicals which do not have a functional group which interferes with the coupling reaction, which process comprises coupling a thiolphenol or phenylalkylmercaptan with a chloromethylpyridine in the pres- ence of DBU under an inert atmosphere. These compounds are leukotriene antagonists and as such can be used in treating various diseases associated with leukotrienes.

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