Method for in vitro assay of soluble fibrin by generating...

Details Method for in vitro assay of soluble fibrin by generating... Method for in vitro assay of soluble fibrin by generating...

C - Chemistry, Metallurgy

12

Q

C12Q 1/56 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2420617

The invention concerns an assay method for soluble fibrin in a sample, which consists in bringing said sample in the presence of a plasminogen activator with high fibrin specificity (PA-Fb-sp) and in measuring the soluble fibrin content of the sample, by measuring the difference between the proportion of fibrin degradation products after breaking down soluble fibrin with PA-Fb-sp and the basic proportion of fibrin degradation products, detected on said sample before it is brought in presence of PA-Fb-sp.

L'invention a pour objet une méthode de dosage de la fibrine soluble dans un échantillon, dans laquelle on met ledit échantillon en présence d'un activateur du plasminogène de forte spécificité pour la fibrine soluble (PA-Fb sp) et l'on mesure la teneur de l'échantillon en fibrine soluble, en mesurant la différence entre le taux de produits de dégradation de la fibrine obtenus après dégradation de la fibrine soluble par le PA-Fb sp et le taux de base des produits de dégradation de la fibrine, déterminé sur ledit échantillon avant sa mise en présence avec le PA-Fb sp.

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