Analgesia method

Details Analgesia method Analgesia method

A - Human Necessities

61

K

A61K 31/57 (2006.01) A61K 31/485 (2006.01) A61K 31/573 (2006.01) A61P 25/04 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2542761

Opioid tolerance is reduced by treating the patient with a neurosteroid of formula (I) wherein R1 is H or methyl; R2 is OH and R3 is H, or R2 and R3 taken together are O; R4 is H or methyl; R5 and R6 are each H, or R5 and R5 taken together are O; R7 is H or methyl; and R8 is H, OH, -OC(=O)CH3, SH, - SC(=O)CH3, Cl, Br or F.

La tolérance aux opiacés peut être réduite par traitement du patient au moyen d'un neurostéroïde représenté par la formule (I) dans cette formule, R¿1? est H ou méthyle; R¿2? est OH et R¿3? est H, ou R¿2? et R¿3? pris ensemble sont O; R¿4? est H ou méthyle; R¿5? et R¿6? sont chacun H, ou R¿5? et R¿5? pris ensemble sont O; R¿7? est H ou méthyle; et R¿8? est H, OH, -OC(=O)CH¿3?, SH, -SC(=O)CH¿3?, Cl, Br ou F.

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