Aryl substituted heterocycles

Details Aryl substituted heterocycles Aryl substituted heterocycles

C - Chemistry, Metallurgy

07

D

C07D 211/08 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 211/14 (2006.01) C07D 211/20 (2006.01) C07D 211/22 (2006.01) C07D 211/24 (2006.01) C07D 211/26 (2006.01) C07D 211/32 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 413/04 (2006.01) C07D 417/00 (2006.01) C07D 491/10 (2006.01) C07D 491/107 (2006.01)

Patent

CA 2124048

ABSTRACT ARYL SUBSTITUTED HETEROCYCLES The present invention concerns the novel aryl substituted heterocycles of formula I, set out below, Image I wherein R2, R3 and R4 have the values defined herein, which antagonize the pharmacological actions of one of the endogenous neuropeptide tachykinins at the neurokinin 2 (NK2) receptor making them useful whenever such antagonism is desired, such as in the treatment of asthma and related conditions. The invention also provides pharmaceutical compositions containing the aryl substituted heterocycles for use in such treatment, methods for their use, and processes and novel intermediates for their manufacture.

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